MMSET regulation of gene expression in t(4;14)+ myeloma

ABSTRACT: We investigated gene expression in isogenic myeloma cell lines with or without overexpressed MMSET protein. MMSET is a histone methyltransferase which methylates lysine 36 on histone H3. Overexpression of MMSET in myeloma leads to a global increase in H3K36 methylation and concomitant decrease in H3K27 methylation. These global changes in histone methylation lead to altered gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57863 | GEO | 2014/09/01

SECONDARY ACCESSION(S): PRJNA248290

REPOSITORIES: GEO