Genomics

Dataset Information

40

DNA methylation in systemic lupus erythematosus patients


ABSTRACT: To screen specific DNA methylation markers in systemic lupus erythematosus (SLE) patient's blood DNA, whole-blood DNAs from 6 female SLE patients and 6 female controls were analyzed by methylation microarray. Overall design: Twelve whole-blood DNA samples from six SLE patients and six controls were analyzed by Illumina HumanMethylation27 BeadChip.

INSTRUMENT(S): Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)

SUBMITTER: Yeong-Wook Song  

PROVIDER: GSE57869 | GEO | 2016-12-27

SECONDARY ACCESSION(S): PRJNA248295

REPOSITORIES: GEO

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Publications

CD3Z hypermethylation is associated with severe clinical manifestations in systemic lupus erythematosus and reduces CD3ζ-chain expression in T cells.

Hong Kyeong-Man KM   Kim Hyun-Kyoung HK   Park Seong-Yeol SY   Poojan Shiv S   Kim Mi-Kyung MK   Sung Joohon J   Tsao Betty P BP   Grossman Jennifer M JM   Rullo Ornella J OJ   Woo Jennifer M P JM   McCurdy Deborah K DK   Rider Lisa G LG   Miller Frederick W FW   Song Yeong-Wook YW  

Rheumatology (Oxford, England) 20170301 3


The importance of hypomethylation in SLE is well recognized; however, the significance of hypermethylation has not been well characterized. We screened hypermethylated marks in SLE and investigated their possible implications.DNA methylation marks were screened in SLE whole-blood DNA by microarray, and two marks ( CD3Z and VHL hypermethylations) were confirmed by a methylation single-base extension method in two independent ethnic cohorts consisting of 207 SLE patients and 151 controls. The corr  ...[more]

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