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Investigation of miRNA expression patterns in Y79 cells

ABSTRACT: We aimed to investigate the miRNA expression patterns in Y79 cells, which are from a representative retinoblastoma cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58092 | GEO | 2014/05/30

SECONDARY ACCESSION(S): PRJNA248893

REPOSITORIES: GEO

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Investigation of miRNA expression patterns in Y79 cells

Project description:We aimed to investigate the miRNA expression patterns in Y79 cells, which are from a representative retinoblastoma cell line. We prepared 3 independent sets of cell lysates of Y79 cells in normal culture conditions. Total RNA was prepared from each set of cell lysates using Trizol reagent.

2014-05-30 | E-GEOD-58092 | biostudies-arrayexpress

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Differential expression of miRNAs in Retinoblastoma cells (Y79) in response to anti-HMGA2 siRNA treatment

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Project description:We hypothesized that Tiam1 is involved in invassiveness of retinoblastoma. The fuctional role of Tiam1 in cell progression and metastasis was tested by siRNA mediated knockdown of Tiam1 in retinoblastoma Y79 cells. The genes de-regulated in response to Tiam1 knockdown was analysed by cDNA microarray in which most of the actin cytoskeleton regulation proteins and apoptotic proteins were de-regulated. our results prove that Tiam1 modulates actin cytoskeleton and cell invasion in retinoblastoma. Retinoblastoma Y79 cells were treated with Tiam1 siRNA for 48hrs and cDNA microarray was performed to analyze the genes regulated by Tiam1 silencing compared to untreated Y79 cells. Experiments were performed in triplicates.

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