Identification of in vivo binding sites of human C2H2-ZF proteins

ABSTRACT: The largest and most diverse class of eukaryotic transcription factors contain Cys2-His2 zinc fingers (C2H2-ZFs), each of which typically binds a DNA nucleotide triplet within a larger binding site. Frequent recombination and diversification of their DNA-contacting residues suggests that these zinc fingers play a prevalent role in adaptive evolution. Very little is known about the function and evolution of the vast majority of C2H2-ZFs, including whether they even bind DNA. We determined in vivo binding sites of 39 human C2H2-ZF proteins, and correlated them with potential functions for these proteins.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58341 | GEO | 2015/02/17

SECONDARY ACCESSION(S): PRJNA252040

REPOSITORIES: GEO