Linking Notch signaling to ischemic stroke

ABSTRACT: Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking susceptibility to ischemic stroke upon challenge. Cellular and molecular analyses of vascular SMCs derived from these animals associate Notch 3 activity to the expression of specific gene targets, whereas genetic rescue experiments unambiguously link Notch 3 function in vessels to the ischemic phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE58368 | GEO | 2014/06/11

SECONDARY ACCESSION(S): PRJNA252379

REPOSITORIES: GEO