Analysis of miRNA expression profiling in 3 samples(normal, cigarette smoking and lung cancer population's serum)

ABSTRACT: Using the highly sensitive miRNA array, we determined the serum miRNAs profiles of 10 non-smokers, 10 smokers and 10 lung cancer patients by miRCURY LNA™ microRNA Arrays. Differential expressed miRNAs were further validated in a larger scale samples. We found that let-7i-3p and miR-154-5p were significantly downregulation in serum of smokers and lung cancer patients. The serum level of let-7i-3p and miR-154-5p is associated with smoking and smoking-related lung cancer.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE58540 | GEO | 2014/06/17

SECONDARY ACCESSION(S): PRJNA252846

REPOSITORIES: GEO