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Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

ABSTRACT: We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58600 | GEO | 2014/10/01

SECONDARY ACCESSION(S): PRJNA253026

REPOSITORIES: GEO

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Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

Project description:We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs. Fifty-one individuals who had never smoked tobacco products and developed PCTs between 1997 and 2008 were studied. A group of 47 carcinoids tumors were analyzed; each with paired tumor-adjacent normal tissue samples (at least 5 cm away from the primary tumors). There are 24 pairs of tumor/normal samples in FF tissues, and 23 pairs of tumor/normal samples in FFPE. The expression status of 1145 miRNAs was generated by Illumina miRNA Arrays.

2014-10-01 | E-GEOD-58600 | biostudies-arrayexpress

Pathways impacted by genomic alterations in pulmonary carcinoid tumors

Project description:Pulmonary carcinoid tumors account for up to 5% of all lung malignancies in adults, comprise 30% of all carcinoid malignancies, and are defined histologically as typical carcinoid (TC) and atypical carcinoid (AC) tumors. The role of specific genomic alterations in the pathogenesis of pulmonary carcinoid tumors remains poorly understood. We sought to identify genomic alterations and pathways that are deregulated in these tumors to find novel therapeutic targets for pulmonary carcinoid tumors.We performed integrated genomic analysis of carcinoid tumors comprising whole genome and exome sequencing, mRNA expression profiling and SNP genotyping of specimens from normal lung, typical and atypical carcinoid, and small cell lung carcinoma (SCLC) to fully represent the lung neuroendocrine tumor spectrum. Pathway analysis of of CNV and gene expression data suggested deregulation of the NF-ĸB and MAPK/ERK pathways. This study identified mutated genes affecting cancer relevant pathways and biological processes that could provide opportunities for developing targeted therapies for pulmonary carcinoid tumors.

2018-01-26 | GSE108055 | GEO

RNA-sequencing from miR-375 knockout and YAP overexpression lung carcinoid (H727) cells.

Project description:We report RNA sequencing data for miR-375 knockout and YAP overexpression lung carcinoid cells (H727). Lung carcinoids are variably aggressive and mechanistically understudied neuroendocrine neoplasms (NENs). Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. miR-375 and YAP are respectively high and low expressed in wild-type H727 cells. Following lentiviral CRISPR/Cas9-mediated miR-375 depletion, we identified distinct transcriptomic changes including dramatic YAP upregulation. Similarly, YAP overexpression resulted in distinct and partially overlapping transcriptomic changes, phenocopying the effects of miR-375 depletion in the same models as above. Pathways analysis and confirmatory real-time PCR studies of shared dysregulated targets indicate that this axis controls neuroendocrine related functions such as neural differentiation, exocytosis, and secretion. Taken together, we provide compelling evidence that a miR-375/YAP axis is a critical mediator of neuroendocrine differentiation and tumorigenesis in lung carcinoid cells.

2021-05-19 | GSE154872 | GEO

Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA.

Project description: Not available

| S-EPMC4124500 | biostudies-literature

Single cell profiling of lung carcinoid tumors

Project description:Tumor tissue of lung carcinoid tumors (pulmonary neuroendocrine tumors) and adjacent normal lung tissue was profiled using scRNA-seq

2022-02-08 | GSE196303 | GEO

Transcription profiling of midgut carcinoid (neuroendocrine) primary tumors and metastasis

Project description:Gene expression profiling of midgut carcinoid (neuroendocrine) primary tumors and metastasis

2008-10-30 | E-TABM-389 | biostudies-arrayexpress

Small Bowel Neuroendocrine Tumors (Carcinoid Tumors)

Project description:Small Bowel Neuroendocrine Tumors (Carcinoid Tumors)

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Enterade in Carcinoid/Non-Carcinoid Syndrome Neuroendocrine Tumor Patients With Quality of Life Limiting Bowel Frequency

Project description:This is an open-label phase II basket study evaluating the ability of enterade to reduce bowel frequency in neuroendocrine tumor (NET) patients with carcinoid syndrome and non-carcinoid syndrome.

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Transcription profiling of human classical midgut carcinoid primary tumors and liver metastasis

Project description:We identify genes presenting a specific expression profile in midgut carcinoid cells, primary carcinoids tumors and liver metastasis were gene profiled. Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis reveal potential novel therapeutic targets and molecular signatures. Experiment Overall Design: Normal and tumoral (carcinoid) cells

2008-11-13 | E-GEOD-9576 | biostudies-arrayexpress

Gene expression profiling of classical midgut carcinoid primary tumors and liver metastasis

2008-10-29 | GSE9576 | GEO

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