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Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh Quiescent C2C12 Myoblasts (G0 enriched)

ABSTRACT: Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of quiescent myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips.

ORGANISM(S): Mus musculus

PROVIDER: GSE58674 | GEO | 2015/06/30

SECONDARY ACCESSION(S): PRJNA253139

REPOSITORIES: GEO

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Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh Quiescent C2C12 Myoblasts (G0 enriched)

Project description:Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of quiescent myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips. Control and knock down cells were synchronized at G0 by suspension culture and total RNA was used to perform microarray analysis

2015-06-30 | E-GEOD-58674 | biostudies-arrayexpress

Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh proliferating C2C12 Myoblasts

Project description:Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of growing myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using NIA15K mouse chips.

2015-06-30 | GSE58675 | GEO

Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh differentiated C2C12 Myoblasts (D28hrs)

Project description:Knockdown of PRDM2 led to precocious differentiation. To understand the molecular basis for this phenotype, we performed microaary analysis of 28hr differentiated myoblasts. Genes differentially regulated by PRDM2 knock down were reveraled by microarray analysis using affymetrix mouse chips.

2015-06-30 | GSE58673 | GEO

Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh proliferating C2C12 Myoblasts

2015-06-30 | E-GEOD-58675 | biostudies-arrayexpress

Transcriptional profiling of PRDM2 Knock down vs.controlGFPsh differentiated C2C12 Myoblasts (D28hrs)

2015-06-30 | E-GEOD-58673 | biostudies-arrayexpress

Identification of targets genes of PRDM2 in G0 arrested myoblasts of C2C12

Project description:PRDM2 directly associates with the Myogenin promoter and repress its transcription. This led to the hypothesis that PRDM2 could potentially associate directly with other promoters and regulate their expression.To gain further insight into the pathways and genes controlled by PRDM2, ChIP-on-Chip analysis was performed using mouse 44K promoter array. Since PRDM2 represses transcription by H3K9 dimethylation, we were interested in determining which targets were occupied by PRDM2 as well as showed enrichment for H3K9me2. Hence ChIP-on-Chip analysis for H3K9me2 was performed to find the overlap between PRDM2 and H3K9me2 marked promoters.

2015-06-30 | GSE58748 | GEO

Identification of targets genes of PRDM2 in G0 arrested myoblasts of C2C12

2015-06-30 | E-GEOD-58748 | biostudies-arrayexpress

Identification of PRDM2 regulated genes in quiescent C2C12 myoblasts.

Project description: Not available

| S-EPMC4664777 | biostudies-literature

Gene expression profiling of PRDM2 Knockdown in proliferating, quiescent and differentiating myoblasts

Project description:Gene expression profiling of PRDM2 Knockdown in proliferating, quiescent and differentiating myoblasts

| PRJNA253136 | ENA

Transcriptional profiling of MLL5 Knock down vs. control C2C12 myoblasts (S phase enriched)

Project description:Knockdown of MLL5 led to deregulation of S phase. To understand the molecular basis for this phenotype, we performed microarray analysis of S phase synchronized myoblasts. Genes differentially regulated by MLL5 knock down were revealed by microarray analysis using NIA15K mouse chips.

2009-03-04 | GSE14931 | GEO

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