Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNA expression profile of PBMCs in OAD mice and control mice

ABSTRACT: MicroRNA expression profiling was performed in PBMCs collected from 12 C57B/6 mice at 7 and 15 days after administration of H2Kb and Isotype antibody. Results: there was a substantial proportion of microRNAs changed over time in OAD mice compared to control mice. Dysregulated microRNA expression in murine obliterative airway disease induced by anti-MHC I antibodies

ORGANISM(S): Mus musculus synthetic construct

PROVIDER: GSE58730 | GEO | 2015/05/31

SECONDARY ACCESSION(S): PRJNA253294

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

MHC Class I antibody induced gene expression in mouse obliterative airway disease

Project description:To further understand the early molecular events in antibody mediated chronic inflammation of the lungs, we utilized a murine Obliterative Airway Disease (OAD) model of native lungs where Abs to MHC class I induces bronchiolar obliteration and fibrosis. This study identified a unique transcriptional profile with a set of genes that were stimulated while another set of genes that were repressed in anti MHC I treated lungs compared to that of isotype treated lungs. Lung transplantation (LTx) is an accepted clinical intervention for various intractable pulmonary dysfunctions. However, de novo Abs to mismatched donor HLA (DSA) predispose lung-grafts to chronic rejection, Bronchiolitis Obliterans Syndrome (BOS). The anti-MHC induced mouse OAD model, the only available preclinical model for study of early pathogenesis following MHC ligation, produces lesions analogous to BOS.

2017-07-29 | GSE71426 | GEO

Transcription profiling of allograft and isograft mouse heterotopic trachea to study murine obliterative airway disease.

Project description:Exploration of genes associated with acute and chronic rejection associated with obliterative airway disease Experiment Overall Design: Untransplanted trachea (controls; n=5) and trachea transplanted into MHC compatible/incompatible recipients at day 4 (n = 5 compatible/5 incompatible), day 14 (n = 5/5) or day 25 (n = 5/5)

2007-10-12 | E-GEOD-3418 | biostudies-arrayexpress

MICE

Project description:Homo sapiens MICE, MHC class I polypeptide-related sequence E (pseudogene) [Source:HGNC Symbol;Acc:HGNC:7094], is expressed in 28 baseline experiment(s);

| ENSG00000273340 | ExpressionAtlas

MICE

Project description:Homo sapiens MICE, MHC class I polypeptide-related sequence E (pseudogene) [Source:HGNC Symbol;Acc:HGNC:7094], is differentially expressed in 18 experiment(s);

| ENSG00000273340 | ExpressionAtlas

Tumor-specific mechanism of Treg enrichment mediated by the integrin avb8

Project description:Subcutaneous tumors from mock transfected LLC or b8 transfected LLC were established on flanks of C57B/6 FoxP3-Ires GFP mice. Mice were treated with isotype control antibodies or anti-b8 and Tregs (CD4+ GFP+) were sorted, pooled and total RNA isolated for RNAseq.

2021-02-23 | GSE158031 | GEO

Mus musculus

Project description:MHC Class I antibody induced gene expression in mouse obliterative airway disease

| PRJNA291185 | ENA

Allograft versus isograft mouse heterotopic tracheal transplant grafts

Project description:Exploration of genes associated with acute and chronic rejection associated with obliterative airway disease Keywords: other

2005-10-08 | GSE3418 | GEO

E-GEOD-21905

Project description:Gene expression in Lineage negative bone marrow cells of C57B/L6 and B.D(Chr5) mice

2015-09-15 | E-GEOD-21905 | ExpressionAtlas

The response of PBMCs and primary airway epithelial cells to Influenza and RSV virus

Project description:This SuperSeries is composed of the following subset Series: GSE32137: The response of murine primary airway epithelial cells to Influenza infection and the importance of Interferon type I signaling in this response [mAEC]. GSE32138: The response of human primary airway epithelial cells to Influenza or RSV infection [hAECs_Agilent]. GSE32139: The response of human primary airway epithelial cells to Influenza or RSV infection [hAECs_Illumina] GSE34205: Transcriptional profile of PBMCs in patients with acute RSV or Influenza infection Refer to individual Series

2012-03-12 | E-GEOD-32140 | biostudies-arrayexpress

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children.

Project description:DNA methylation profiling of airway epithelial cells (AECs) and peripheral blood mononuclear cells (PBMCs) from normal, atopic and asthmatic subjects. The Illumina GoldenGate Methylation Cancer Panel I was used to obtain DNA methylation profiles across approximately 1505 CpGs in AECs and PBMCs. Samples included 7 healthy, 9 atopic, 4 atopic asthmatic and 5 non-atopic asthmatic subjects. Please note that only some of the samples are matched (i.e. AECs and PBMCs from the same individual) due to DNA quality or sample collection (i.e. only one sample (AEC or PBMC) was collected from the patient).

2012-05-09 | GSE37853 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data