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Zebrafish early transcriptional response to viral haemorrhagic septicemia rhabdovirus (VHSV) challenge vs2

ABSTRACT: We describe here the transcripts induced after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV). Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in both fins and internal organs (pooled spleen, head kidney and liver).

ORGANISM(S): Danio rerio

PROVIDER: GSE58823 | GEO | 2015/04/17

SECONDARY ACCESSION(S): PRJNA253593

REPOSITORIES: GEO

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Zebrafish early transcriptional response to viral haemorrhagic septicemia rhabdovirus (VHSV) challenge vs2

Project description:We describe here the transcripts induced after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV). Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in both fins and internal organs (pooled spleen, head kidney and liver). VHSV-induced gene expression in zebrafish fins and organs was measured at 2 days after infection. Four independent experiments were performed for each treatment and their corresponding controls

2015-04-17 | E-GEOD-58823 | biostudies-arrayexpress

Gene expression profiles after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV)

Project description:We describe for the first time transcripts induced after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV). Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in both fins and internal organs (pooled spleen, head kidney and liver).

2010-02-01 | GSE19049 | GEO

Gene expression profiles after infection of zebrafish with Viral haemorrhagic septicemia rhabdovirus (VHSV)

Project description:We describe for the first time transcripts induced after infection of zebrafish with VHSV. Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied using qRT-PCR in both fins and internal organs (pooled spleen, head kidney and liver).

2010-02-01 | GSE19503 | GEO

Gene expression profiles after infection of rainbow trout with viral hemorrhagic septicemia virus (VHSV)

Project description:We describe here transcripts induced after intraperitoneal injection of rainbow trout with 2 different viruses, both belonging to strain 23.75 of viral hemorrhagic septicemia virus (VHSV): a deleted Nv gene (dNV) virus and a wild type (wt) virus. Two days after infection, differentially expressed transcript levels from selected immune-related trout genes were studied in internal organs (spleen and head kidney). Fishes were divided in two groups (3 fishes per group). The first group was intraperitoneally injected with 100000 pfu per trout of dNV VHSV, while the second group was injected with 100000 pfu/trout of wt VHSV. All fishes were sacrificed two days post infection.

2015-03-05 | E-GEOD-43285 | biostudies-arrayexpress

Gene expression profiles after infection of rainbow trout with viral hemorrhagic septicemia virus (VHSV)

2015-03-05 | GSE43285 | GEO

Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (microRNA-Seq)

Project description:Leiocassis longirostris is a common fish variety widely cultivated in China, however, bacterial haemorrhagic septicemia, which occurs easily during the breeding process, can cause great economic loss for farmers. To understand the immune response of L. longirostris to Aeromonas hydrophila infection, Illumina sequencing was employed to identify changes in the mRNA and miRNA in spleen tissue. In this study, a total of 92.16 and 95.61 million (M) high-quality transcriptome reads were generated from the control group (CG) and experimental group (EG) spleen samples, respectively, and 207 up-regulated and 185 down-regulated genes were identified. These genes were enriched in 29 GO terms and 30 KEGG pathways (P ≤ 0.05), including cytokine-cytokine receptor interaction and complement and coagulation cascades, with 17 up-regulated genes and 12 down-regulated genes in the EG relative to the CG. Based on the zebrafish genome, miRNA-seq identified a total of 343 miRNAs, of which 15 were up-regulated and 10 were down-regulated (fold-change ≥ 2 or ≤ 0.5 and P ≤ 0.05). Target gene prediction and KEGG enrichment analysis revealed that all of the target genes were concentrated in 13 pathways associated with immune response, including the mTOR signaling pathway and the TGF-beta signaling pathway. The expression patterns of 8 differentially expressed genes and 4 miRNAs involved in immune response were validated by quantitative real-time RT-PCR. These results provide insights into the molecular mechanisms underlying the effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris.

2020-01-30 | GSE138968 | GEO

Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (RNA-Seq)

2020-01-30 | GSE138967 | GEO

Gene expression profiles after injection of zebrafish with NV (non virion) recombinant protein from Viral Hemorrhagic Septicemia Virus (VHSV)

Project description:NV is a viral protein only present in the genus Novirhabdovirus (fam Rhabdoviridae), its function is not well characterized yet. In this study we try to shed some light in the biological function of this viral protein in the zebrafish. We describe here transcripts induced after injection of adult zebrafish with NV recombinant protein of VHSV. Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in zebrafish internal organs (pooled spleen and head kidney).

2017-06-15 | GSE54076 | GEO

Gene expression profile after injection of recombinant deleted non-virion protein gene (NV) VHSV

Project description:The function of the non-virion protein (NV) of the Viral hemorrhagic septicemia virus (VHSV) has been long questioned but it still remains unknown. We report here the differences in gene expression profiles of trouts infected with deleted NV VHSV or wild type VHSV so that it could shed some light on the issue.

2013-08-17 | GSE37330 | GEO

Gene expression profile after injection of recombinant deleted non-virion protein gene (NV) VHSV

2013-08-17 | GSE37330 | GEO

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