Genomics

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Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions


ABSTRACT: During inflammation, neutrophils are rapidly mobilized from the bone marrow storage pool into peripheral blood to subsequently enter lesional sites where most of them rapidly undergo apoptosis. Monocytes constitute a second wave of inflammatory immigrates giving rise to long-lived macrophages and dendritic cell subsets. According to descriptive immunophenotypic and cell culture studies, neutrophils may directly “transdifferentiate” into monocytes/macrophages. We here provide mechanistic data in human supporting the existence of this cellular pathway. Global transcriptional profiling of neutrophil-dervived monocytic cells revealed close resemblance of gene expression with monocytes and a clear separation of these cells from neutrophils.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58920 | GEO | 2014/07/11

SECONDARY ACCESSION(S): PRJNA253926

REPOSITORIES: GEO

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