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Expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

ABSTRACT: High throughput sequencing of miRNAs collected from tammar milk at different time points of lactation showed high levels of miRNA secreted in milk and allowed the identification of differentially expressed milk miRNAs during the lactation cycle as putative markers of mammary gland activity and functional candidate signals to assist growth and timed development of the young. Comparative analysis of miRNA distribution in milk and blood serum suggests that milk miRNAs are primarily expressed from mammary gland rather than transferred from maternal circulating blood, likely through a new putative exosomal secretory pathway.

ORGANISM(S): Notamacropus eugenii

PROVIDER: GSE58941 | GEO | 2015/09/11

SECONDARY ACCESSION(S): PRJNA253954

REPOSITORIES: GEO

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Expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

Project description:High throughput sequencing of miRNAs collected from tammar milk at different time points of lactation showed high levels of miRNA secreted in milk and allowed the identification of differentially expressed milk miRNAs during the lactation cycle as putative markers of mammary gland activity and functional candidate signals to assist growth and timed development of the young. Comparative analysis of miRNA distribution in milk and blood serum suggests that milk miRNAs are primarily expressed from mammary gland rather than transferred from maternal circulating blood, likely through a new putative exosomal secretory pathway. 8 profiles were produced. Duplicates of day175

2015-09-11 | E-GEOD-58941 | biostudies-arrayexpress

Gene expression in the mammary gland of the tammar wallaby during the lactation cycle

Project description:In this study we use microarray technology to identify differentially expressed genes in the tammar wallaby mammary gland during the lactation cycle. We have focused on gene expression changes in the tammar mammary gland as it shifts from one lactation phase to the next.

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Expression profiles of microRNAs from lactating and non-lactating bovine mammary glands and identification of miRNA related to lactation.

Project description:miRNAs have been implicated in the regulation of milk protein synthesis and development of mammary gland. However, the function of miRNAs in regulating lactation is unclear. Therefore, the elucidation of miRNA expression profiles in MG provides a crucial entry into the understanding of the mechanisms of lactation initiation. Our present work is to examine miRNA expression profiles in bovine mammary gland, and to evaluate miRNAs function through the identification of differentially expressed miRNA between lactation and non-lactation mammary gland. Identification of novel miRNAs highlights the important function of low abundance and less conserved miRNAs. An interaction network of known miRNAs and their target genes around the lactation function was constructed to postulate the functional roles of miRNAs in mammary gland. This integrated analysis provides important information that will inspire further experimental investigations into the field of miRNAs and their targets during lactation.

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Distinct lactation-associated macrophages exist in murine mammary tissue and human milk

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2023-06-23 | PXD041711 | Pride

miRNAs involed in lactation of cow mammary gland

Project description:We investigated miRNA expression in Holstein dairy cow of mammary gland with different producing quality milk using high-throughput sequence and qRT-PCR techniques. miRNA libraries were constructed from mammary gland tissues taken from a high producing quality milk and a low producing quality milk Holstein dairy cow, the small RNA digitalization analysis based on HiSeq high-throughput sequencing takes the SBS-sequencing by synthesis.The libraries included 4732 miRNAs. A total of 124 miRNAs in the high producing quality milk mammary gland showed significant differences in expression compared to low producing quality milk mammary gland (P<0.05). Conclusion: Our study provides a broad view of the bovine mammary gland small RNA expression profile characteristics. Differences in types and expression levels of miRNAs were observed between high producing quality milk and a low producing quality milk Holstein dairy cow

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Distinct lactation-associated macrophages exist in murine mammary tissue and human milk [RNA-seq: human]

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Distinct lactation-associated macrophages exist in murine mammary tissue and human milk [RNA-seq: mouse]

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The bovine mammary transcriptome: functional adaptation of the mammary gland during the lactation cycle

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2012-03-01 | GSE19055 | GEO

Expression profiles of microRNAs from lactating and non-lactating bovine mammary glands

2012-11-26 | E-GEOD-39000 | biostudies-arrayexpress

Discovery and Comparative Transcriptome Profiling of Dairy Goat MicroRNAs from Dry Period and Peak Lactation Mammary Gland Tissues

Project description:In this study, two small RNA libraries were constructed using dry period and peak lactation dairy goat mammary gland tissues and sequenced by the Illumina Solexa high-throughput sequencing system. A total of 346 conserved and 95 novel miRNAs were identified in the dairy goat. The expression of miRNAs was confirmed by qRT-PCR in nine tissues and the mammary gland during development cycles. In addition, several candidate miRNAs that may be involved in mammary gland development and lactation were found by the comparison of miRNA expression profiles among different tissue and developmental stages of the mammary gland. This study provides the identification and profile of miRNAs related to the biology of the mammary gland in the dairy goat. The identification of these miRNAs could contribute to understanding the molecular mechanisms of lactation physiology and the development of the mammary gland in the dairy goat.

2014-12-31 | GSE41815 | GEO

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