Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)
SUBMITTER: Josee Dostie
PROVIDER: GSE59027 | GEO | 2015-12-30
SECONDARY ACCESSION(S): PRJNA254154
REPOSITORIES: GEO
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Fraser James J Ferrai Carmelo C Chiariello Andrea M AM Schueler Markus M Rito Tiago T Laudanno Giovanni G Barbieri Mariano M Moore Benjamin L BL Kraemer Dorothee C A DC Aitken Stuart S Xie Sheila Q SQ Morris Kelly J KJ Itoh Masayoshi M Kawaji Hideya H Jaeger Ines I Hayashizaki Yoshihide Y Carninci Piero P Forrest Alistair R R AR Semple Colin A CA Dostie Josée J Pombo Ana A Nicodemi Mario M
Molecular systems biology 20151223 12
Mammalian chromosomes fold into arrays of megabase-sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher-order organization remains elusive. Here, we investigate TAD higher-order interactions with Hi-C through neuronal differentiation and show that they form a hierarchy of domains-within-domains (metaTADs) extending across genomic scales ...[more]