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Mouse Liver: Tumors vs Two Week Transgene Expression vs Normal

ABSTRACT: Transcriptional Profiling of mouse liver tissues comparing normal tissues, tissues with two weeks expression of transgene, and tumors arising from transgene expression after hepatocy transplantation using the comparative hepatocyte growth assay Experimental groups: Control (hPAP marker gene); Normal Liver Expressing Transgene for Two Weeks; Liver Tumors Expressing Transgene

ORGANISM(S): Mus musculus

PROVIDER: GSE59194 | GEO | 2014/08/15

SECONDARY ACCESSION(S): PRJNA254741

REPOSITORIES: GEO

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Mouse Liver: Tumors vs Two Week Transgene Expression vs Normal

Project description:Transcriptional Profiling of mouse liver tissues comparing normal tissues, tissues with two weeks expression of transgene, and tumors arising from transgene expression after hepatocy transplantation using the comparative hepatocyte growth assay Experimental groups: Control (hPAP marker gene); Normal Liver Expressing Transgene for Two Weeks; Liver Tumors Expressing Transgene Twenty-Conditon Experiment: 1 Control Group (hPAP marker transgene); 10 Groups of Normal Liver Expressing Different Transgene for 2 weeks; 9 Groups of Tumors Arising from Different Transgene

2014-08-15 | E-GEOD-59194 | biostudies-arrayexpress

Mouse Liver: Tumors vs livers with transgene turned off for 4 weeks vs livers with transgene turned off for 12 weeks vs Normal

Project description:Transcriptional Profiling of mouse liver tissues comparing normal tissues, livers arising from transgene expression after hepatocy transplantation using the comparative hepatocyte growth assay, and livers with transgene turned off for 4 and 12 weeks. Experimental groups: Control normal liver; Endstage liver tumors, livers with transgene turned off for 4 weeks, and livers with transgene turned off for 12 weeks.

2014-07-15 | GSE59211 | GEO

Mus musculus

Project description:Mouse Liver: Tumors vs livers with transgene turned off for 4 weeks vs livers with transgene turned off for 12 weeks vs Normal

| PRJNA254740 | ENA

Premature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [RRBS]

Project description:We report a reprogrammable mouse system in which reprogramming factor expression in vivo can be controlled temporally by treatment with doxycycline (Dox). Transient expression of reprogramming factors in vivo results in tumor development in various tissues, consisting of undifferentiated dysplastic cells. We analyzed the kidney tumors developed in reprogrammable mice for global gene expressions and DNA methylations. Reprogrammable mice at 4 weeks of age were treated with Dox for 7 days followed by the withdrawal. Seven days after the withdrawal, kidney tumors were analyzed for gene expressions and DNA methylations with microarray and RRBS method, respectively. Normal kidney tissue at the same age and ES cells were analyzed as controls. To examine the early changes of gene expressions, transgene-expressing kidney cells were FACS sorted and they are utilized for microarray analysis. Primary liver tumors in reprogrammable mice and transplanted secondary kidney tumors in the subcutaneous tissues of immnodeficient mice were also analyzed for gene expressions.

2014-02-13 | E-GEOD-52303 | biostudies-arrayexpress

Premature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]

2014-02-13 | E-GEOD-51786 | biostudies-arrayexpress

Mus musculus

Project description:Mouse Liver: Tumors vs Two Week Transgene Expression vs Normal

| PRJNA254741 | ENA

Effects of oocyte-specific PIK3CA* transgene knock-in in ovaries

Project description:To investigate the transcriptomic changes during the development and growth of ovarian granulosa cell tumors derived by oocyte-specific PIK3CA* transgene overexpression

2023-12-31 | GSE233313 | GEO

Albumosomes formed by pre-folding albumin in cytoplasm of hepatocytes maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease

Project description:Wildtype (WT) and albumin-knockout (AKO) were fed with normal diet. We harvested the liver tissues from WT and AKO mice at 3-week, 8-week, and 10-month of age. We then performed gene expression profiling analysis using data obtained from RNA-seq of the six different liver tissues. Wildtype (WT) and albumin-knockout (AKO) mice were fed with Normal diet (ND) or Western diet (WD) for 8 weeks from the age of 8 weeks. We harvested the liver tissues from WT-ND, WT-WD, AKO-ND, AKO-WD mice . We then performed gene expression profiling analysis using data obtained from RNA-seq of the four different liver tissues. Wildtype (WT) mice fed with HFD from the age of 8 weeks were injected by 17-AAG at the 3rd, 4th, 5th, 6.5th, and 8th weeks of the HFD feeding process. The control group was injected by the solvent. Another group of mice at the same age was fed with normal diet (ND). We harvested the liver tissues ND, Ctrl, and 17-AAG mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of the three different liver tissues.

2023-01-20 | GSE222922 | GEO

Genome-wide analysis of the altered gene expression in the transgenic mice ectopically expressing the human SRY. [liver]

Project description:Analysis of the effects of an ectopically expressed human SRY (hSRY) on gene expression in the mouse liver. We hypothesize that aberrant expression of the human SRY gene could affect the development and physiology of transgenic mice. To test this hypothesis we have established a Cre-LoxP transgene activation system, thereby activating and expressing the hSRY transgene at the single-cell embryonic stage. Such transgenic mice were born of similar sizes as non-transgenic littermates, but retard in postnatal growth and all die within two weeks of age. To determine the molecular changes associated with such phenotypes, we have analyzed the transcriptomes of livers of pups expressing (hSRY-ON) and not-expressing (hSRY-OFF) the hSRY transgene. The results provide important information demonstrating that ectopic expression of hSRY resulted in altered expression patterns of numerous genes associating with the development of hepatic system and pathogenesis of hepatic system diseases in the liver.

2017-04-16 | GSE97846 | GEO

Transcription profiling of whole lungs from mice expressing an inducible dominant negative BMPR2 transgene to study the effect of BMPR2 on gene expression.

Project description:Mice expressing a doxycycline-inducible dominant negative BMPR2 transgene expressed only in smooth muscle are activated for one or eight weeks, and compared to transactivator-only mice also fed doxycycline. All mice are 12 weeks of old at sacrifice. Experiment Overall Design: Each chip is a pool of three individual mice, to reduce variability. The transactivator-only mice are controls. The other mice all had elevated RV pressures at time of sacrifice. RNA was prepared from whole lung.

2007-11-27 | E-GEOD-5255 | biostudies-arrayexpress

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