Differences in platelet miRNA profiles between patients with coronary artery disease and healthy controls.

ABSTRACT: Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. The aim of this study was to investigate whether differences in miRNA expression levels in platelets can be found (i) between patients with premature CAD and healthy controls and (ii) within healthy controls after and before aspirin and statin administration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59421 | GEO | 2015/06/22

SECONDARY ACCESSION(S): PRJNA255363

REPOSITORIES: GEO