Validation of the C. elegans model using juglone as a positive control for oxidative stress

ABSTRACT: To confirm the suitability of C. elegans as a model organism, preliminary gene expression experiments were performed using juglone (5-hydroxy-1,4-naphthoquinone; 97% pure; Sigma-Aldrich, St-Louis, MO), an ROS-generator, as a positive control of oxidative stress (d'Arcy Doherty et al. 1987; Leiers et al. 2003). Reproduction tests were initially performed to establish the sub-lethal effect concentrations used in the microarray experiments.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE59475 | GEO | 2014/07/17

SECONDARY ACCESSION(S): PRJNA255403

REPOSITORIES: GEO