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Expression data from MCF7 cells depleted of the cohesin subunit RAD21 and treated with estrogen or vehicle

ABSTRACT: RAD21 is a subunit of cohesin. Cohesin is maninly known for its role in holding sister chromatids together during cell-division but it also plays a role in gene regulation. Genome wide study in MCF7 cells have shown that cohesin co-binds with estrogen receptor alpha at numerous sites. To identify estrogen sensitive genes that are influenced by cohesin, a microarray expression analysis was conducted in MCF7 cells lacking the cohesin subunit RAD21. Global changes in gene expression were identified in cells treated with Control/RAD21 siRNA and stimulated with estrogen/vehicle thereafter.

ORGANISM(S): Homo sapiens

PROVIDER: GSE59908 | GEO | 2016/01/30

SECONDARY ACCESSION(S): PRJNA257049

REPOSITORIES: GEO

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Expression data from zebrafish embryos homozygous mutant for the cohesin subunit Rad21

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Expression data from Rad21 knock-down in ES cells

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