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DNA methylation data from 11 normal and 9 chronic periodontitis patients from site USC

ABSTRACT: Microarray methylation (Infinium®HumanMethylation 450 BeadChip from Illumina) was performed on 11 normal and 9 chronic periodontitis (CP) patients

ORGANISM(S): Homo sapiens

PROVIDER: GSE59939 | GEO | 2015/07/29

SECONDARY ACCESSION(S): PRJNA257103

REPOSITORIES: GEO

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DNA methylation data from 11 normal and 9 chronic periodontitis patients from site USC

Project description:Microarray methylation (Infinium®HumanMethylation 450 BeadChip from Illumina) was performed on 11 normal and 9 chronic periodontitis (CP) patients Bisulphite converted DNA from the 20 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip

2015-07-29 | E-GEOD-59939 | biostudies-arrayexpress

DNA methylation data from 12 normal and 10 chronic periodontitis patients from site OCI

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Project description:This study evaluated the transcriptome of healthy gingival tissue in patients with a history of generalized aggressive periodontitis (GAgP) and chronic periodontitis (CP) and in subjects with no history of periodontitis (H), using microarray analysis.

2017-03-29 | GSE79705 | GEO

Genome-wide methylation analysis identifies core set of hypermethylated genes in CIMP-H colorectal cancer

Project description:DNA methylation was analysed using the Illumina Infinium HumanMethylation 450 Beadchip in 94 matched tissue pairs of colorectal cancer patients.

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Proteomic Analysis of Whole Saliva in Chronic Periodontitis

Project description:Periodontitis is a chronic inflammatory disease resulting from a dysbiosis of the dental biofilm and a dysregulated host response in susceptible individuals. It is characterized by periodontal attachment destruction, bone resorption, and eventual tooth loss. Salivary biomarkers have been sought to predict and prevent periodontitis. This comparative study analyzed the salivary proteome of 30 individuals with chronic periodontitis (CP) and 10 with periodontal health (PH), and correlated specific proteins with clinical parameters of disease by using mass spectrometry. Stimulated whole saliva was obtained and pooled for 5 healthy controls and 15 CP patients, precipitated with TCA, digested enzymatically with trypsin and analyzed by an LTQ Orbitrap Velos equipped with a nanoelectrospray ion source. A wide range of salivary proteins of various functions was significantly reduced in CP individuals, whereas salivary acidic proline-rich phosphoprotein, submaxillary gland androgen-regulated protein, histatin, fatty acid-binding protein, thioredoxin, and cystatin were predominant in diseased patients and correlated significantly with signs of periodontal attachment loss and inflammation. Specific salivary proteins were associated with PH and CP. These differences in salivary proteome profiles may contribute to the identification of disease indicators or signatures and the improvement of periodontal diagnosis.

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Comparative miRNA expression profiles in individuals with chronic or aggressive periodontitis

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2018-06-26 | GSE116209 | GEO

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