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The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

ABSTRACT: Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice

ORGANISM(S): Mus musculus

PROVIDER: GSE59940 | GEO | 2015/07/25

SECONDARY ACCESSION(S): PRJNA257097

REPOSITORIES: GEO

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The Nlrp12 inflammasome negatively regulates NOD2-mediated adjuvanticity, endotoxic shock and host defence afforded by an immunomodulatory muropeptide.

Project description:Transcriptional profiling of intestinal response to Citrobacter rodentium in wild-type and Nlrp12-deficient mice Four-conditions experiment, Nlrp12-deficient mouse infected by Citrobacter rodentium at day 7 versus non-infected Nlrp12-deficient mice with two biologicals replicates , Wild-type mouse infected by Citrobacter rodentium at day 7 versus non-infected Wild-type mice with two biologicals replicates and Nlrp12-deficient mouse infected by Citrobacter rodentium versus Control mouse infected by Citrobacter rodentium at 2 differents times ( day 0 and post infection at day 7 ) with three biologicals replicates

2015-07-25 | E-GEOD-59940 | biostudies-arrayexpress

Colonic gene expression in healthy and C. rodentium-infected mice lacking epithelial MHCII

Project description:We generated conditional knockout of MHCII in intestinal epithelial cells in C57BL/6 mice (I-AbΔIEC) and compared their colonic transcriptome in control and Citrobacter rodentium infected mice. I-AbWT or I-AbΔIEC mice were orally gavaged with Citrobacter rodentium DBS100

2020-02-08 | GSE144952 | GEO

Mutation analysis of parental and 10 avirulent C. rodentium isolates from the feces of C3H/HeJ mice

Project description:We report that dietary iron protects mice from infection by Citrobacter rodentium. Iron induces a state of insulin resistance and increases glucose availability in the gut, thereby attenutating C. rodentium virulence. Additionally the pathogen appears to be driven towards a long-term commensal state. Here, we identify mutations in persistent and avirulent Citrobacter rodentium isolates from mice given an iron supplemented diet.

2018-09-21 | GSE116595 | GEO

Transcriptome analysis of infected and uninfected mice with Citrobacter rodentium

Project description:Transcriptome analysis of infected and uninfected mice with Citrobacter rodentium

2018-09-21 | GSE111097 | GEO

RNA-Seq of C. rodentium

Project description:Whole genome trancription study of Citrobacter rodentium grown in rich media.

2011-02-12 | E-MTAB-502 | biostudies-arrayexpress

Analysis of the evolutionary adaptation of an AraC-like global regulatory protein in the murine enteric pathogen Citrobacter rodentium

Project description:An experiment to test the equivalence of the Citrobacter rodentium RegA and E.Coli SMS 3-5 homologue

2015-02-19 | GSE57689 | GEO

Effect of Glucuronic acid on Citrobacter rodentium

Project description:Previous experiments have shown that hexuronates regulate EHEC virulence, here we look at glucuronic acid effect on citrobacter rodentium

2024-01-09 | GSE252543 | GEO

Effect of microbial β-glucuronidases on Citrobacter rodentium mice infection

Project description:Previous experiments have shown that hexuronates regulate EHEC virulence, here we look at glucuronic acid effect on citrobacter rodentium

2024-01-13 | GSE252823 | GEO

Polysaccharides from Sargassum fusiforme protect mice against Citrobacter rodentium infection through intestinal microbiota-drived microRNA-92a-3p

Project description:To explore the regulatory mechanism of intestinal flora in Citrobacter rodentium -induced intestinal infection by transcriptome analysis at miRNA molecular level.

2024-03-04 | GSE260446 | GEO

Project description:Citrobacter rodentium

| PRJNA326023 | ENA

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