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Expression analysis of KHR and KR oral tumors with intact or deficient Notch1

ABSTRACT: KHR and KR tumors grow faster when deficient for Notch1. The hypothesis was to test for differences in gene expression between KHR and KHR oral tumors with intact or deficient Notch1 haplotypes.

ORGANISM(S): Mus musculus

PROVIDER: GSE59951 | GEO | 2015/09/09

SECONDARY ACCESSION(S): PRJNA257155

REPOSITORIES: GEO

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Expression analysis of KHR and KR oral tumors with intact or deficient Notch1

Project description:KHR and KR tumors grow faster when deficient for Notch1. The hypothesis was to test for differences in gene expression between KHR and KHR oral tumors with intact or deficient Notch1 haplotypes. Total RNA was isolated for KHR (n=5), KHR-N+/- (n=4), KHR-N-/- (n=5), KR-N+/- (n=5), KR-N-/- (n=4) oral tumors. Expression profiling was performed using the Illumina MouseRef-8 v2 (GPL6885) array. Studies were conducted using tumors from C57BL/6 mice.

2015-09-09 | E-GEOD-59951 | biostudies-arrayexpress

Expression profile of oral tumors from KR versus KHR mice treated with tamoxifen

Project description:kRas (KR) tumors grow faster when expressing kRas and HPV E6E7 (KHR). The hypothesis was to test for differences in gene expression between KR and KHR oral tumors.

2022-06-14 | GSE97417 | GEO

Transcriptome analysis of Drosophila Kr-h1 mutants

Project description:Transcriptome analysis (RNA-Seq) was performed to identify Kr-h1 target genes. Message RNAs were extracted from wildtype and kr-h1[7] homozygous 3rd instar larvae at 100 hr after egg laying (two biological replicates for each genotype).

2016-12-31 | GSE85863 | GEO

Mus musculus

Project description:Expression analysis of KHR and KR oral tumors with intact or deficient Notch1

| PRJNA257155 | ENA

Notch1 regulates hepatic thrombopoietin production

Project description:Notch signaling regulates cell-fate decisions in several developmental processes and cell functions. However, a role for Notch in hepatic thrombopoietin (TPO) production remains unclear. We noted thrombocytopenia in mice with hepatic Notch1 deficiency, and so investigated TPO production and other features of platelets in these mice. We found that the liver ultrastructure and hepatocyte function were comparable between control mice and Notch1-deficient mice. However, the Notch1-deficient mice had significantly lower plasma TPO and hepatic TPO mRNA levels, concomitant with lower numbers of platelets and impaired megakaryocyte differentiation and maturation, which were rescued by addition of exogenous TPO. Additionally, JAK2/STAT3 phosphorylation was significantly inhibited in Notch1-deficient hepatocytes, consistent with the RNA-seq analysis. JAK2/STAT3 phosphorylation and TPO production was also impaired in cultured Notch1-deficient hepatocytes after treatment with desialylated platelets. Consistently, hepatocyte-specific Notch1 deletion inhibited JAK2/STAT3 phosphorylation and hepatic TPO production induced by administration of desialylated platelets in vivo. Interestingly, Notch1 deficiency downregulated the expression of HES5 but not HES1. Moreover, desialylated platelets promoted the binding of HES5 to JAK2/STAT3, leading to JAK2/STAT3 phosphorylation and pathway activation in hepatocytes. Hepatocyte Ashwell-Morell receptor (AMR) (asialoglycoprotein receptor 1, ASGR1) physically associates with Notch1 and inhibition of AMR impaired Notch1 signaling activation and hepatic TPO production. Furthermore, blockage of Dll4 on desialylated platelets inhibited hepatocyte Notch1 activation and HES5 expression, JAK2/STAT3 phosphorylation and subsequent TPO production. In conclusion, our study identifies a novel regulatory role of Notch1 in hepatic TPO production, indicating that it might be a target for modulating TPO level.

2024-04-12 | GSE250529 | GEO

ChIP-seq for Kr-h1 in Harpegnathos brains

Project description:We performed ChIP-seq with a new Kr-h1 antibody in the central brains of in established gamergates (day 120) and age-matched workers

2021-11-04 | GSE161206 | GEO

RNA-seq in Harpegnathos central brains after Kr-h1 knockdown

Project description:Central brain RNA-seq after control and Kr-h1 knockdown in d10 worker or gamergate.

2021-11-04 | GSE161205 | GEO

Deinococcus hopiensis KR-140

Project description:Deinococcus hopiensis KR-140 genome sequencing

| PRJNA42099 | ENA

Expression data of in vitro co-cultures comparing PKCa-KR- vs MIEV-transduced B lineage cells

Project description:We performed Affymetrix microarray gene chip analysis on PKCa-KR- vs MIEV retrovirally transduced mouse B lineage cells that had been co-cultured for 17-23 days (late co-culture) to establish B cell transformation. Expression analysis was performed between PKCa-KR and MIEV samples.

2021-10-02 | GSE185075 | GEO

Expression data in the absence of Notch1 in hair follicles

Project description:Notch1 deficient hair matrix keratinocytes have lower mitotic rates, resulting in smaller follicles with fewer cells. In addition, the ratio of melanocytes to keratinocytes is greatly reduced. Microarray was performed to study downstream mechanism of Notch1-deficiency Keywords: genetic modification

2007-01-26 | GSE6867 | GEO

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