Genomics

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MicroRNA profile of tumorigenic cells during formation of pulmonary adenocarcinoma


ABSTRACT: Study designed to obtain microRNA profile of tumorigenic Sca-1+CD34+ cells during the formation of pulmonary adenocarcinoma. After intranasal infection with adenovirus CRE (Ad-Cre), lung adenocarcinoma was identified pathologically in Lox-stop-lox Kras (LSL-Kras) G12D mice. Sca-1+CD34+ cells were sorted by flow cytometry and tested for the tumor-initiating ability to undergo self-renewal and differentiation. MiRNA profile was obtained from the microarray and further confirmed by qRT-PCR.The function of miRNAs was predicted bioinformatically, and miR-294 was verified to explore its relationship with tumor migration and invasion.

ORGANISM(S): Mus musculus Murid gammaherpesvirus 4 Murid betaherpesvirus 1

PROVIDER: GSE60001 | GEO | 2014/08/02

SECONDARY ACCESSION(S): PRJNA257255

REPOSITORIES: GEO

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