Transcriptomics

Dataset Information

48

Gene expressions in pancreatic cancer cells


ABSTRACT: We used time-dependent spheroidal cultures of pancreatic cancer cells to investigate how spatiotemporal regulation in spheroids induces epithelial-mesenchymal plasticity (EMP). We generated a round bottom spheroidal model using β3 integrin-negative pancreatic cancer cells in 2D conventional monolayer cultures, and compared the expression of integrin signaling-related genes that induce spheroidal geometry to determine if spheroidal geometry induces integrin switching. Overall design: To identify the potential genes whose expression changed in response to culture conditions, we performed microarray analysis of gene expression in human MIA PaCa-2 cells grown under monolayer and spheroid culture conditions for 6 days and 13 days.

INSTRUMENT(S): Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)

ORGANISM(S): Homo sapiens  

SUBMITTER: Jung Min Kim  

PROVIDER: GSE60139 | GEO |

SECONDARY ACCESSION(S): PRJNA257555

REPOSITORIES: GEO

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