Transcriptomics,Genomics

Dataset Information

54

Investigation of the pathogenesis of H1N1 influenza virus and swine streptococcus suis serotype 2 co-infection in pigs by microarray analysis


ABSTRACT: Swine H1N1 influenza virus and streptococcus suis serotype 2 (SS2) are two important contributors to the porcine respiratory disease complex, which have significant economic impacts. Clinically, swine influenza virus and swine streptococcus suis co-infection is common, which will increase the mortality. However, the pathogenesis of the co-infection remains largely unkown. To explore it, gene expression profiling was to performed to detect comprehensive analysis of the global host response induced by H1N1 virus infection alone, SS2 infection alone, H1N1-SS2 co-infection and PBS control. Overall design: A total of 12 healthy pigs were randomly allocated to 4 groups with 3 pigs each: H1N1 group, SS2 group, H1N1-SS2 group and control group. At the age of 35 days, pigs in H1N1 and H1N1-SS2 groups were intranasaly challenged with A/swine/Hubei/101/2009(H1N1) strain and others were treated similarly with PBS. 3 days after H1N1 virus challenge, pigs in SS2 and H1N1-SS2 groups were inoculated intranasally with PBS containing SS2 strain ZY05, others were treated similarly with PBS.

INSTRUMENT(S): Agilent-020109 Porcine Gene Expression Microarray (44K) (Probe Name version)

SUBMITTER: Lin xian  

PROVIDER: GSE60172 | GEO | 2016-09-10

SECONDARY ACCESSION(S): PRJNA257663

REPOSITORIES: GEO

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Publications

Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis.

Lin Xian X   Huang Canhui C   Shi Jian J   Wang Ruifang R   Sun Xin X   Liu Xiaokun X   Zhao Lianzhong L   Jin Meilin M  

PloS one 20150423 4


Swine influenza virus and Streptococcus suis are two important contributors to the porcine respiratory disease complex, and both have significant economic impacts. Clinically, influenza virus and Streptococcus suis co-infections in pigs are very common, which often contribute to severe pneumonia and can increase the mortality. However, the co-infection pathogenesis in pigs is unclear. In the present study, co-infection experiments were performed using swine H1N1 influenza virus and Streptococcus  ...[more]

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