Evaluation of Niacinamide effects on murine primary macrophage transcriptional regulation and cell cycle progression.

ABSTRACT: Murine MafB/c-MAF double KO (Maf-DKO) primary macrophages are known for their unlimited non-tumorigenic self-renewal ability (Aziz et al., 2009). In an in vitro screen for cytokines and small molecules we identified Niacinamide (NAM) a potent inhibitor of their proliferative potential characterized by a reversible cell cycle arrest.

ORGANISM(S): Mus musculus

PROVIDER: GSE60187 | GEO | 2017/08/21

SECONDARY ACCESSION(S): PRJNA257703

REPOSITORIES: GEO