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Effect of Glucocorticoids on microRNA, lncRNA and mRNA Expression Profiles of the Human Bone Microcirculatory Endothelial Cells from Femoral Head

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60333 | GEO | 2015/01/05

SECONDARY ACCESSION(S): PRJNA258050

REPOSITORIES: GEO

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Effect of Glucocorticoids on lncRNA and mRNA Expression Profiles of the Human Bone Microcirculatory Endothelial Cells from Femoral Head

Project description:Appropriate gene expression patterns form the basis for bone microcirculatory endothelial cells’ function and bone morphology. Although previous studies have elucidated the impact of hydrocortisone on bone microcirculatory endothelial cells’ specific gene expression, the exact differential transcriptomes and comprehensive gene expression profiles remain unknown. We have investigated the mRNA and lncRNA expression patterns before and after hydrocortisone administration of bone microcirculatory endothelial cells. At mRNAs level totally 518 differentially expressed genes were identified. Furthermore, we identified 73 upregulated and 166 downregulated long non-coding RNAs after administration of hydrocortisone. These RNAs appeared to be highly important to gene co-expression network. Transcriptomic analysis of bone microcirculatory endothelial cells from human samples is highly informative due to their relevance to the large number of expressed genes. Our study provides a very valuable basis for investigation of genes, regulation and their co-expression network contributing to hydrocortisone induced disorders.

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Effect of glucocorticoids on lncRNA and mRNA expression profiles of the bone microcirculatory endothelial cells from femur head of Homo sapiens.

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Effect of Glucocorticoids on microRNA Expression Profile of the Human Bone Microcirculatory Endothelial Cells from Femoral Head

Project description:Appropriate gene expression patterns form the basis for bone microcirculatory endothelial cells’ function and bone morphology. Although previous studies have elucidated the impact of hydrocortisone on bone microcirculatory endothelial cells’ specific gene expression, the exact differential transcriptomes and comprehensive gene expression profiles remain unknown. We have investigated the microRNA expression patterns before and after hydrocortisone administration of bone microcirculatory endothelial cells. Only 5 microRNAs were Benjamini-Hochberg characterized over 368 microRNAs candidates. Transcriptomic analysis of bone microcirculatory endothelial cells from human samples is highly informative due to their relevance to the large number of expressed genes. Our study provides a very valuable basis for investigation of genes, regulation and their co-expression network contributing to hydrocortisone induced disorders.

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Effect of Glucocorticoids on microRNA, lncRNA and mRNA Expression Profiles of the Human Bone Microcirculatory Endothelial Cells from Femoral Head

Project description:Effect of Glucocorticoids on microRNA, lncRNA and mRNA Expression Profiles of the Human Bone Microcirculatory Endothelial Cells from Femoral Head

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Effect of Glucocorticoids on microRNA, lncRNA and mRNA Expression Profile of the Human Bone Microcirculatory Endothelial Cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-05 | E-GEOD-60333 | biostudies-arrayexpress

Effect of Glucocorticoids on lncRNA and mRNA Expression Profile of the Human Bone Microcirculatory Endothelial Cells

Project description:Appropriate gene expression patterns form the basis for bone microcirculatory endothelial cellsM-bM-^@M-^Y function and bone morphology. Although previous studies have elucidated the impact of hydrocortisone on bone microcirculatory endothelial cellsM-bM-^@M-^Y specific gene expression, the exact differential transcriptomes and comprehensive gene expression profiles remain unknown. We have investigated the mRNA and lncRNA expression patterns before and after hydrocortisone administration of bone microcirculatory endothelial cells. At mRNAs level totally 518 differentially expressed genes were identified. Furthermore, we identified 73 upregulated and 166 downregulated long non-coding RNAs after administration of hydrocortisone. These RNAs appeared to be highly important to gene co-expression network. Transcriptomic analysis of bone microcirculatory endothelial cells from human samples is highly informative due to their relevance to the large number of expressed genes. Our study provides a very valuable basis for investigation of genes, regulation and their co-expression network contributing to hydrocortisone induced disorders. Two-condition experiment, hydrocortisone treated vs. untreated bone microcirculatory endothelial cells. Biological replicates: 8 control replicates, 8 treated replicates.

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