Esophageal cancer intratumor heterogeneity revealed by multi-region whole exome sequencing and aCGH

ABSTRACT: Cancer is a disease of the genome. Many genomic abnormalities have been found in a variety of cancer types, which are believed to be attributable to tumorigenesis as well as resistance to treatment and recurrence. Genomic heterogeneity in the same type of cancer or within a tumor reveals the complexity of cancer biology so that intratumor heterogeneity has become an inherent feature of cancer. In this study, we use whole-exome sequencing and array comparative genomic hybridization technology to examine the mutational profiling and copy number changes from multi-region samples within an esophageal cancer in order to understand the genomic phylogeny in the evolution of intratumor heterogeneity in esophageal cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60625 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA258665

REPOSITORIES: GEO