Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease

ABSTRACT: Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention.

ORGANISM(S): Mus musculus

PROVIDER: GSE60691 | GEO | 2015/12/21

SECONDARY ACCESSION(S): PRJNA259286

REPOSITORIES: GEO