CGGBP1 inhibits cytosine methylation at repetitive DNA sequences

ABSTRACT: By depleting CGGBP1 in normal human fibroblasts and by performing genome-wide sequencing (with and without bisulfite conversion) we show that upon CGGBP1 depletion cytosine methylation increases significantly at repeat regions. Using Pacbio sequencing of Alu and LINE-1 repeats amplified genome-wide from bisulfite converted DNA, we further establish the cytosine methylation-inhibitory functions of CGGBP1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60784 | GEO | 2015/08/26

SECONDARY ACCESSION(S): PRJNA259540

REPOSITORIES: GEO