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Expression microarray analysis of HaCaT epidermal keratinocyte treated with AdcaRAS/dnRAS, p53 siRNA, and/or TGF-beta

ABSTRACT: We demonstrate that activation of Ras and TGF-β pathways strengthens the binding of p63 to its genomic sites and modulates the expression of p63 target genes. Our findings support a model of mutual inhibition between ΔNp63α, DUSP6 and mutant p53 downstream of oncogenic Ras and TGF-β.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60813 | GEO | 2016/08/12

SECONDARY ACCESSION(S): PRJNA259608

REPOSITORIES: GEO

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p63 binding regions in HaCaT epidermal keratinocyte infected with caRAS/dnRAS and treated with TGF-beta

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