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Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [ChIP-Seq]

ABSTRACT: Analysis of CTCF binding in Wehi-231 with TFII-I knockdown compare to Wehi-231 wt.

ORGANISM(S): Mus musculus

PROVIDER: GSE60917 | GEO | 2014/08/29

SECONDARY ACCESSION(S): PRJNA259806

REPOSITORIES: GEO

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Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [ChIP-Seq]

Project description:Analysis of CTCF binding in Wehi-231 with TFII-I knockdown compare to Wehi-231 wt. ChIP experiment of CTCF in Wehi-231-CT and Wehi-231-shTFII-I

2014-08-29 | E-GEOD-60917 | biostudies-arrayexpress

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [gene expression]

Project description:Analysis of the effect of TFII-I depletion on gene expression Wehi-231 cell lines. Total RNA were extract from shCT and shTFII-I Wehi-231 cells.

2014-08-29 | E-GEOD-60915 | biostudies-arrayexpress

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I [gene expression]

Project description:Analysis of the effect of TFII-I depletion on gene expression Wehi-231 cell lines.

2014-08-29 | GSE60915 | GEO

Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I.

Project description: Not available

| S-EPMC4343169 | biostudies-literature

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I

Project description:Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I

| PRJNA259804 | ENA

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-29 | E-GEOD-60918 | biostudies-arrayexpress

Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-08-29 | GSE60918 | GEO

Orphan nuclear receptor COUP-TFII enhances myofibroblasts glycolysis leading to kidney fibrosis

Project description:Recent studies demonstrated that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic perturbation in fibrosis, however, has been elusive. COUP-TFII (also known as NR2F2) is an important regulator of glucose and lipid metabolism. Its contribution to organ fibrosis is undefined. Here, we found increased COUP-TFII expression in myofibroblasts in human fibrotic kidneys, lungs, kidney organoids, and mouse kidneys after injury. Genetic ablation of COUP-TFII in mice resulted in attenuation of injury-induced kidney fibrosis. A non-biased proteomic study revealed the suppression of fatty acid oxidation and the enhancement of glycolysis pathways in COUP-TFII overexpressing fibroblasts. Overexpression of COUP-TFII in fibroblasts induced augmented glycolysis and production of alpha smooth muscle actin (αSMA) and collagen1. Knockout of COUP-TFII decreased glycolysis and collagen1 levels in fibroblasts. Chip-qPCR revealed the binding of COUP-TFII on the promoter of PGC1α. Overexpression of COUP-TFII reduced the cellular level of PGC1α. Targeting COUP-TFII serves as a novel treatment approach for mitigating fibrosis in chronic kidney disease and potentially fibrosis in other organs.

2021-04-27 | PXD024035 | Pride

Genes regulated by COUP-TFII inhibitor

Project description:The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases including prostate cancer, heart failure and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it an intriguing therapeutic target. Here, we identified a potent and specific COUP-TFII inhibitor through high-throughput screening. The inhibitor specifically suppressed COUP-TFII activity to regulate its target genes.

2020-05-12 | GSE142475 | GEO

Atrial Identity Is Determined by A COUP-TFII Regulatory Network (RNA)

Project description:Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP- TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T-tubules. We used microarrays to examine the molecular profile of cardiomyocyte-specific COUP-TFII knockout adult atria in comparison with that of normal atria.

2013-06-07 | GSE46496 | GEO

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