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Transcriptional profiling of human monocyte-derived macrophages

ABSTRACT: In this study we compared the response of human monocyte-derived macrophages differentiated with either granulocyte-macrophage colony-stimulating factor (GM-CSF) or macrophage colony-stimulating factor (M-CSF) to the most common activation stimuli: LPS plus interferon-γ to induce macrophage polarization towards the M1 type or IL-4 to induce macrophage polarization towards the M2a type. Additionally, IL-10 was used to drive M-CSF-primed macrophages into the M2c state. We used the the whole-human genome microarray to determine genes that were up- or downregulated by the activation stimuli in both macrophage lineages, with focus on genes implicated in immune response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE61298 | GEO | 2018/05/22

REPOSITORIES: GEO

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Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation?

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2015-03-12 | E-GEOD-57614 | biostudies-arrayexpress

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Transcriptomic analysis of human polarized macrophages: more than one role of alternative activation?

2015-03-12 | GSE57614 | GEO

Gene Expression Analysis in Different Macrophage Phenotypes

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2016-08-10 | E-GEOD-85346 | biostudies-arrayexpress

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2015-08-01 | E-GEOD-55029 | biostudies-arrayexpress

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