A novel small-molecule inhibitor of STAT5A/STAT5B with therapeutic potential for prostate cancer and CML

ABSTRACT: We assessed the gene expression profiles induced by both genetic and pharmacological knockdown of Stat5a/b in CML cells. Stat5 was suppressed in K562 cells by lentiviral expression of Stat5 shRNA vs. scramble control for 6 days or by treatment of the cells with IST5-002 (5 µM) for 48 h.

ORGANISM(S): Homo sapiens

PROVIDER: GSE61312 | GEO | 2015/07/01

SECONDARY ACCESSION(S): PRJNA260723

REPOSITORIES: GEO