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Combinatorial effects of estrogen with progestogens or androgen in the breast cancer cell line ZR-75-1

ABSTRACT: Cells were cotreated with dihydrotestosterone, progesterone or medroxyprogesterone acetate and estrdiol to assess the combinatorial effects of hormone exposure in breast cancer cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE61368 | GEO | 2015/10/18

SECONDARY ACCESSION(S): PRJNA260887

REPOSITORIES: GEO

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Combinatorial effects of estrogen with progestogens or androgen in the breast cancer cell line ZR-75-1

Project description:Cells were cotreated with dihydrotestosterone, progesterone or medroxyprogesterone acetate and estrdiol to assess the combinatorial effects of hormone exposure in breast cancer cells Cells were plated in hormone stripped media for 56h, followed by treatment for 16h with 10nM of the nominated hormone(s)

2015-10-18 | E-GEOD-61368 | biostudies-arrayexpress

Cotreatment effects of estrogen with progestogens or dihydrotestosterone in the breast cancer cell line T-74D

Project description:Cells were cotreated with estrogen and dihydrotestosterone, progesterone or medroxyprogesterone acetate to assess the combinatorial effects of progestogens or androgens with estrogen in T47D breast cancer cells

2015-10-18 | GSE62243 | GEO

ChIP-seq of the androgen receptor (AR) in MDAMB453 cells after androgen stimulation

Project description:Serum starved MDAMB453 cells were serum starved and treated for 4 hours with vehicle control (ethanol), 5α-dihydrotestosterone (DHT; 10nM) or medroxyprogesterone acetate (MPA; 10nM). AR binidng peaks were determined. Subsequent analysis showed that binding sites for androgen receptor are enriched at breast cancer risk loci.

2015-10-16 | GSE74069 | GEO

Comparison of MPA regulated gene expression profiles to those regulated by PROG, DHT, DEX

Project description:Medroxyprogesterone acetate (MPA) is a progestin that can bind to and activate progesterone, androgen and glucocorticoid receptors. However, it is not known which receptor mediates MPA action in a cellular context where all three of these receptors are co-expressed and functional. This microarray experiment was performed to compare the transcriptomes induced by MPA and the cognate ligands for these receptors ie progesterone (PROG), 5a-dihydrotestosterone (DHT) and dexamethasone (DEX) in breast cancer cells to determine which was most similar to MPA.

2020-01-22 | GSE139870 | GEO

ZR-75-1 microarray expression data

Project description:Testing the hormonal response of ZR-75-1 cells to estrogen, androgens, and a combination of both homones, with view determining the crosstalk between the transcriptional programs mediated by these hormones in breast cancer cells, and comparison with matched ChIP sequencing data for AR and ERalpha. Data analysis demonstrated reciprocal interference between 5α-dihydrotestosterone (DHT)- and estradiol (E2)-induced transcriptional programs. Specifically, regulation of 26% of E2 and 15% of DHT target genes was significantly affected by cotreatment with the other hormone, in the majority of cases (78-83%) antagonistically. Pathway analysis suggested that DHT co-treatment, for example, depleted E2-regulted pathways in cell survival and proliferation.

2012-10-03 | GSE38132 | GEO

ZR-75-1 microarray expression data

2012-10-03 | E-GEOD-38132 | biostudies-arrayexpress

Differential effects of progesterone and medroxyprogesterone acetate on normal breast cells

2011-05-30 | GSE23500 | GEO

Transcriptome of human decidual cells treated by siRNA targeting FOXO1

Project description:Here we report the gene expression profile of in vitro cultured human endometrial stromal cells treated with siRNA targeting FOXO1 piror to eutherian differentiation media exposure. The eutherian differentiation media contains cyclic AMP (cAMP) analogue 8-Br-cAMP and the progesterone (P4) analogue medroxyprogesterone acetate (MPA).

2018-06-21 | GSE115832 | GEO

Differential effects of progesterone and medroxyprogesterone acetate on normal breast cells

Project description:Comparison between the effects of progesterone (P4) and medroxyprogesterone acetate (MPA) combined to estradiol (E2) on gene expression in normal breast cells to provide insight on their possible different impact on breast cancer risk in vivo. Total RNA obtained from cultures of normal human breast epithelial cells (HBE) under E2, E2+MPA and E2+P4 six hour treatments, compared to untreated HBE cells

2011-05-30 | E-GEOD-23500 | biostudies-arrayexpress

Single-cell RNA sequencing of MCF-7, T-47D and ZR-75-1 breast cancer cell lines treated with estrogen and progesterone

Project description:In order to study transcriptional heterogeneity in response to hormone stimulation in breast cancer, we performed high-throughput single-cell RNA sequencing (scRNA-seq) on 3 breast cancer cell lines that differ in their nuclear receptor expression levels. MCF-7, T-47D and ZR-75-1 cell lines were treated with estrogen and progesterone alone or in combination and collected at different time points. Hash-tagging antibodies were used to identify samples.

2022-09-08 | GSE154873 | GEO

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