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Streptococcus pyogenes MGAS5005: control vs heme exposure

ABSTRACT: Transcriptional profiling of Streptococcus pyogenes MGAS5005 cells comparing control untreated GAS cells with GAS cells exposed to 4uM heme for 1.5 h

ORGANISM(S): Streptococcus pyogenes

PROVIDER: GSE61415 | GEO | 2014/09/16

SECONDARY ACCESSION(S): PRJNA261032

REPOSITORIES: GEO

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Streptococcus pyogenes MGAS5005: control vs heme exposure

Project description:Transcriptional profiling of Streptococcus pyogenes MGAS5005 cells comparing control untreated GAS cells with GAS cells exposed to 4uM heme for 1.5 h Two-condition experiment, untreated vs. heme-treated MGAS5005 cells. Biological replicates: 3 control, 3 Heme-treated, independantly grown and harvested. One replicate per array.

2014-09-16 | E-GEOD-61415 | biostudies-arrayexpress

Rgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101

2008-02-01 | GSE7341 | GEO

Rgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101

Project description:Rgg-dependent transcriptional regulation in Streptococcus pyogenes strains MGAS5005 and CS101 was analyzed during post-exponential phase of growth Keywords: strain comparion, post-exponential growth, rgg mutant Microarray analysis was performed using RNA samples isolated from wild-type MGAS5005 and CS101 strains as well as their rgg mutant strains during post-exponential phase of growth

2010-05-26 | E-GEOD-7341 | biostudies-arrayexpress

Streptococcus pyogenes

Project description:Streptococcus pyogenes MGAS5005: control vs heme exposure

| PRJNA261032 | ENA

Streptococcus pyogenes strain:MGAS5005 & mutants

Project description:Streptococcus pyogenes strain:MGAS5005 & mutants Transcriptome or Gene expression

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Multiple roles of RNase Y in Streptococcus pyogenes mRNA metabolism

Project description:Streptococcus pyogenes (Group A streptococcus, GAS) is an important human pathogen that causes a variety of infectious diseases and sequelae. Recent studies showed virulence factor expression was controlled at multiple levels, including the post-transcriptional regulation. In this study, we examined the global half-lives of S. pyogenes mRNAs and explored the role RNase Y played in mRNA metabolism with microarray analysis. key word: genetic modification

2013-02-01 | GSE40198 | GEO

Proteome analysis of extracellular vesicles released from Streptococcus pyogenes

Project description:Streptococcus pyogenes (Group A Streptococcus: GAS) is a major human pathogen that causes streptococcal pharyngitis, skin and soft-tissue infections, and life-threatening conditions such as streptococcal toxic shock syndrome (STSS). A large number of virulence-related genes are encoded on GAS genomes, which are involved in host-pathogen interaction, colonization, immune invasion, and long-term survival within hosts, causing the diverse symptoms. Here, we investigated the interaction between GAS-derived extracellular vesicles and host cells in order to reveal pathogenicity mechanisms induced by GAS infection.

2021-05-17 | PXD026040 | JPOST Repository

Counteractive balancing of transcriptome expression involving CodY and CovRS in Streptococcus pyogenes

Project description:Streptococcus pyogenes (group A Streptococcus, GAS) responds to environmental changes in a manner that results in an adaptive regulation of the transcriptome. Global transcriptional regulators are able to integrate important extracellular and intracellular information and are responsible for modulation of the transcriptional network. The roles of several global transcriptional regulators in adaptation and virulence gene expression have been described. In this study we used microarray to investigate the regulatory roles of CodY and CovRS played in Streptococcus pyogenes. keywords: genetic modification

2011-03-01 | GSE26590 | GEO

Counteractive balancing of transcriptome expression involving CodY and CovRS in Streptococcus pyogenes

2011-03-01 | E-GEOD-26590 | biostudies-arrayexpress

Transcriptomic analysis of Streptococcus pyogenescolonizing the vaginal mucosa identifies hupY, an MtsR-regulated adhesin involved in heme utilization

Project description:Streptococcus pyogenes (Group A Strep, GAS) is a serious human pathogen with the ability to colonize mucosal surfaces such as the nasopharynx and vaginal tract, often leading to infections such as pharyngitis and vulvovaginitis. We present genome-wide RNASeq data showing the transcriptomic changes GAS undergoes during vaginal colonization. These data reveal that the regulon controlled by MtsR, a master metal regulator, is activated during vaginal colonization. This regulon includes two genes highly expressed during vaginal colonization, hupYZ. Here we show that HupY binds heme in vitro, affects intracellular concentrations of iron, and is essential for proper growth of GAS using hemoglobin or serum as the sole iron source. HupY is also important for murine vaginal colonization of both GAS and the related vaginal colonizer and pathogen, Streptococcus agalactiae (Group B Strep, GBS). These data provide essential information on the link between metal regulation and mucosal colonization in both GAS and GBS.

2019-05-31 | GSE131982 | GEO

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