Gene expression profiles in rat lung following intratracheal instillation with impurity-free single-wall carbon nanotubes

ABSTRACT: To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physicochemical properties of impurity-free single-wall carbon nanotubes (SWCNTs). We have prepared two types of dispersed the SWCNTs, namely relatively small bundles and a short linear shape (CNT-1) and large bundles and a long linear shape (CNT-2), and attempted to characterize time-dependent changes in the gene expression of lung tissues until 90 days after intratracheal instillation with SWCNTs suspensions at 0.4 mg injected dose per rat.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE61483 | GEO | 2014/09/17

SECONDARY ACCESSION(S): PRJNA261287

REPOSITORIES: GEO