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Dataset Information

41

ChIP-chip of MCF7 Sox2 regulatory region 2 transcription activity reporter unresponsive and reporter responsive breast cancer cells


ABSTRACT: We found that MCF7 and ZR751 Sox2-expressing breast cancer cell lines comprise of cells with heterogeneous Sox2 transcription activity reporter response. A small subset of Sox2 reporter responsive cells are more tumourigenic than the bulk Sox2 reporter unresponsive cells. We questioned whether Sox2 exhibit differential gene promoter occupancies in the two cell subsets to govern differential gene expression patterns. Overall design: Sox2 ChIP in reporter unresponsive (RU) and reporter responsive (RR) cells (duplicate samples) were compared. IgG ChIP in RU and RR cells served as the negative controls.

INSTRUMENT(S): NimbleGen Human ChIP-CHIP 3 x 720k REFSEQ Promoter Array [090618_HG18_Refseq_Prom_ChIP and 100718_HG18_Refseq_Prom_ChIP]

ORGANISM(S): Homo sapiens  

SUBMITTER: Raymond Lai 

PROVIDER: GSE61703 | GEO |

SECONDARY ACCESSION(S): PRJNA261895

REPOSITORIES: GEO

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