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Inhibition of AK4 expression increases drug sensitivity and elevates mitochondrial ATP synthesis

ABSTRACT: Adenylate kinase 4 (AK4) is localized in the mitochondrial matrix, and is believed to be involved in stress, drug resistance, the malignant transformation of cancer, and ATP regulation. We produced AK4 knockdown HeLa cells by using shRNA and used these to analyze resistance, and found that sensitivity to hypoxia and drugs increased.

ORGANISM(S): Homo sapiens

PROVIDER: GSE61843 | GEO | 2016/03/31

SECONDARY ACCESSION(S): PRJNA262546

REPOSITORIES: GEO

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Inhibition of AK4 expression increases drug sensitivity and elevates mitochondrial ATP synthesis

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