Transcriptomics,Genomics

Dataset Information

22

Whole Genome Drosophila Embryogenesis Time Course


ABSTRACT: We analyzed the expression of every gene in the Drosophila genome during the first 24 hours of development to examine patterns of gene activatio and repression responsbile for early development. Keywords: Expression Arrays time course Overall design: We isolated mRNA from each time point and hybridized against a reference set of RNA that was pooled from time points across all of development.

INSTRUMENT(S): Yale Drosophila melanogaster 14K Whole Genome Embryogenesis Timecourse

SUBMITTER: Christopher E Mason  

PROVIDER: GSE6186 | GEO | 2006-11-02

SECONDARY ACCESSION(S): PRJNA100659

REPOSITORIES: GEO

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Publications

Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis.

Hooper Sean D SD   Boué Stephanie S   Krause Roland R   Jensen Lars J LJ   Mason Christopher E CE   Ghanim Murad M   White Kevin P KP   Furlong Eileen E M EE   Bork Peer P  

Molecular systems biology 20070116


Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript l  ...[more]

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