Transcriptomics

Dataset Information

22

Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages


ABSTRACT: Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. However, the sets of inducible genes, the candidate enhancers, and the GR motifs within them, were highly-divergent between the two species. Overall design: 3 biological replicates of a 6 point time series for the transcriptional response to dexamethasone 100nM

INSTRUMENT(S): [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

ORGANISM(S): Mus musculus  

SUBMITTER: Alasdair W Jubb   

PROVIDER: GSE61879 | GEO |

SECONDARY ACCESSION(S): PRJNA262585

REPOSITORIES: GEO

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