Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Primary and adjacent non-malignant tissue samples of 100 HCC patients (mRNA)

ABSTRACT: Genome-wide mRNA expression profiles of 100 primary and matched non-malignant tissues of HCC patients from a Singapore patient cohort. HCC is a hetergenous disease and it is important to understand the underlying molecular mechanisms. Here, we studied the role of microRNAs in HCC by integrating microRNA and gene expression profiles of HCC patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62043 | GEO | 2016/02/18

SECONDARY ACCESSION(S): PRJNA263020

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Primary and adjacent non-malignant tissue samples of 100 HCC patients (miRNA)

2016-02-18 | GSE62007 | GEO

Primary and adjacent non-malignant tissue samples of 100 HCC patients (miRNA)

Project description:Genome-wide miRNA expression profiles of 100 primary and matched non-malignant tissues of HCC patients from a Singapore patient cohort. HCC is a hetergenous disease and it is important to understand the underlying molecular mechanisms. Here, we studied the role of microRNAs in HCC by integrating microRNA and gene expression profiles of HCC patients. Profiling of 100 primary and adjacent non-malignant HCC tissue samples on mirXplore two-color miRNA expression microarray. All tissues were collected with approvals from the National Cancer Centre, Singapore; the Research Ethics Review Committee; and signed patient informed consent.

2016-02-18 | E-GEOD-62007 | biostudies-arrayexpress

Primary and adjacent non-malignant tissue samples of 100 HCC patients (mRNA)

Project description:Genome-wide mRNA expression profiles of 100 primary and matched non-malignant tissues of HCC patients from a Singapore patient cohort. HCC is a hetergenous disease and it is important to understand the underlying molecular mechanisms. Here, we studied the role of microRNAs in HCC by integrating microRNA and gene expression profiles of HCC patients. Profiling of 100 primary and adjacent non-malignant HCC tissue samples on Agilent two-color whole human genome gene expression microarray (design G4112F). All tissues were collected with approvals from the National Cancer Centre, Singapore; the Research Ethics Review Committee; and signed patient informed consent.

2016-02-18 | E-GEOD-62043 | biostudies-arrayexpress

Primary and adjacent non-malignant tissue samples of 100 HCC patients

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-02-18 | GSE62044 | GEO

Primary and adjacent non-malignant tissue samples of 100 HCC patients

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-18 | E-GEOD-62044 | biostudies-arrayexpress

Expression data from paired human primary HCC tissues and adjacent non-cancerous liver tissues.

Project description:Hepatic cirrhosis or advanced fibrosis caused by chronic hepatitis may be the main risk factor contributing to the occurrence of HCC. Growing clinical evidence show that patients with hepatic cirrhosis or advanced fibrosis may have a 7-fold higher incidence rate of HCC than those without, suggesting a crucial role of inflammation-carcinogenesis malignant transformation in HCC development and progression. We used microarrays to detail the global programme of gene expression underlying inflammation-carcinogenesis malignant transformation in HCC and identified distinct classes of up-regulated and down-regulated genes during this process

2021-02-12 | GSE166163 | GEO

Applied Biosystems Human TaqMan Low Density Array (TLDA) in HCC tumor and adjacent non-tumor tissues

Project description:MicroRNAs (miRNAs) are aberrant expressed in hepatocellular carcinoma (HCC) tissue and play a central role in diverse biological processes. We conducted a genome-wide miRNAs screening in 10 pairs of HCC tumor and adjacent non-tumor tissues to test the hypothesis that dysregulation of miRNAs in HCC tumor tissue are partially due to aberrant methylation in relevant miRNAs host genes. Taqman low density arrays were used to examine miRNA profiles in paired HCC tissues, and quantitative RT-PCR was used to validate candidate miRNAs for both discovery and validation sets. A cross-sectional study was conducted in 10 HCC tumor tissues and 10 adjacent non-tumor tissues in Columbia University Medical Center (CUMC), which is approved by the Institutional Review Board.

2014-02-08 | E-GEOD-54751 | biostudies-arrayexpress

Applied Biosystems Human TaqMan Low Density Array (TLDA) in HCC tumor and adjacent non-tumor tissues

2014-02-08 | GSE54751 | GEO

Differential proteomics between AFP-negative HCC and adjacent non-tumor liver tissue

Project description:We screened and identified novel proteins in AFP-negative HCC tissue that were differentially expressed related to levels in adjacent non-tumor liver tissue using SWATH-MS proteome technology

2021-11-02 | PXD028854 | Pride

Micro RNA expression from human hepatocellular carcinoma (HCC) specimens from patients undergoing liver transplantation.

Project description:Current selection criteria for liver transplant in patients with HCC (the Milan criteria) do not incorporate biologic metrics. MiRNA expression profiles correlate with HCC recurrence after transplant and can add significant value to the Milan criteria. MiRNA expression profiles were studied in HCC specimens from patients undergoing liver transplant and correlated with their tumor recurrence status and Milan criteria status.

2011-10-14 | E-GEOD-30297 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data