Genomics

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Myelomatous plasma cells display an aberrant gene expression pattern similar to that observed in normal memory B cells


ABSTRACT: In the current study we have evaluated the hypothesis that myelomatous plasma cells (mPCs) might simultaneously gain the gene expression pattern acquired by a normal plasma cell (PC) along its maduration process but without losing the expression pattern displayed by memory B cells (MBCs) which confer these cells their long-term viability. Thus, mPCs would aberrantly share both activation and anti-apoptotic gene expression patterns from PCs and MBCs counterparts, respectively. This information may be an important contribution to the field of multiple myeloma (MM) research.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62188 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA263472

REPOSITORIES: GEO

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