Dataset Information


Gene expression profiles of FGF-treated prostate cancer cells

ABSTRACT: Fibroblast growth factor 23 (FGF23) is a member of endocrine FGF subfamily, which includes FGF19, FGF21 and FGF23. We explored the question of whether different FGF ligands are activating the same transcriptional program in prostate cancer (PCa) cells or whether there are unique or partially overlapping activities as well. Overall design: We stimulated biological duplicates of LNCaP cells with FGF2 (classical FGF), FGF19 or FGF23 and collected mRNAs after 24 hrs. We then carried out expression array analysis using Agilent expression arrays. Multiple group comparisons

INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

SUBMITTER: Chad Creighton  

PROVIDER: GSE62192 | GEO | 2015-05-29



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FGF23 promotes prostate cancer progression.

Feng Shu S   Wang Jianghua J   Zhang Yiqun Y   Creighton Chad J CJ   Ittmann Michael M  

Oncotarget 20150701 19

Prostate cancer is the most common cancer in US men and the second leading cause of cancer deaths. Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. We now show that FGF23 is expressed as an autocrine growth factor in all prostate cancer cell lines tested and is present at increased levels in prostate cancer tissues. Exogenous FGF23 enhances prolif  ...[more]

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