Transcriptomics,Genomics

Dataset Information

19

Heart expression data from WT and reverb alpha KO mice after short ischemia/reperfusion at ZT0, ZT12


ABSTRACT: Nuclear receptor Reverb alpha is a component of circadian rythm which could be evolved in cardioprotection strategy. We test if pharmacological modulation of these target could be suitable for cardioprotection after ischemia reperfusion injury We used microarrays to detail the global programme of gene expression Overall design: Heart ischemia reperfusion were performed using Langendorff isolated heart model and twenty minutes stop flow ishemia with twenty minutes reperfusion.

INSTRUMENT(S): [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]

SUBMITTER: Lefebvre Philippe 

PROVIDER: GSE62457 | GEO | 2018-03-15

REPOSITORIES: GEO

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Publications


BACKGROUND:On-pump cardiac surgery provokes a predictable perioperative myocardial ischaemia-reperfusion injury which is associated with poor clinical outcomes. We determined the occurrence of time-of-the-day variation in perioperative myocardial injury in patients undergoing aortic valve replacement and its molecular mechanisms. METHODS:We studied the incidence of major adverse cardiac events in a prospective observational single-centre cohort study of patients with severe aortic stenosis and p  ...[more]

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