Transcriptomics,Genomics

Dataset Information

40

Neuronal activity promotes glioma growth


ABSTRACT: Secreted molecules from active neurons promote glioma growth Overall design: Cells were treated with either conditioned media from blue light exposed WT brain slices, or conditioned media from optogenetically stimulated Thy1::ChR2 slices

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Humsa Venkatesh  

PROVIDER: GSE62563 | GEO | 2017-08-29

SECONDARY ACCESSION(S): PRJNA264418

REPOSITORIES: GEO

Dataset's files

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Publications


Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins of high-grade glioma (HGG). By using optogenetic control of cortical neuronal activity in a patient-derived pediatric glioblastoma xenograft model, we demonstrate that active neurons similarly promote HGG proliferation and growth in vivo. Conditioned medium from optogenetically stimulated cortical slices promoted proliferation of pediatric and adult patient-deriv  ...[more]

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