Genomics

Dataset Information

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Elucidating the effects of the macrophage environment on the efficacy of anti-mycobacterial drugs


ABSTRACT: We examined the transcriptional responses of intracellular M. tuberculosis exposed to different front-line drugs during macrophage infection. Our data reveal that Mtb experiences amplification of multiple host-derived pressures following drug exposure. The stresses from the host environment have a dominant impact on Mtb gene expression to the extent that the transcriptional profiles cluster according to environment, ie. broth vs host cell, rather than drug.

ORGANISM(S): Mycobacterium tuberculosis Mycobacterium tuberculosis CDC1551

PROVIDER: GSE62942 | GEO | 2016/02/21

SECONDARY ACCESSION(S): PRJNA266241

REPOSITORIES: GEO

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