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Effect of oxidative stress on the association of long noncoding RNA and mRNA with ribosomes

ABSTRACT: In this study we analysed the association of long noncoding RNAs (lncRNAs) and mRNAs with ribosomes in control and oxidatively stressed (2hr treatment with H2O2) MRC5 fibroblasts. A custom microarray was used to analyze the stress-induced distribution changes of transcripts between the non-translating (free RNP and 80S), low-translating (two, three and four ribosomes), and highly-translating (five and more ribosomes) pools in three experiments. The finding suggests that stress-induced lncRNAs showed a higher polysome occupancy as compared to the transcripts of coding genes in response to oxidative stress.

ORGANISM(S): Homo sapiens

PROVIDER: GSE63112 | GEO | 2015/05/28

SECONDARY ACCESSION(S): PRJNA266639

REPOSITORIES: GEO

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