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Expression profiling of T.rubrum treated with PH11B

ABSTRACT: T. rubrum was treated with PH11B,a potent eucaryotic fatty acid synthase inhibtor. A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PH11B were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: fatty acid synthase inhibition

ORGANISM(S): Trichophyton rubrum

PROVIDER: GSE6336 | GEO | 2007/11/21

SECONDARY ACCESSION(S): PRJNA99635

REPOSITORIES: GEO

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Expression profiling of T.rubrum treated with PH11B

Project description:T. rubrum was treated with PH11B,a potent eucaryotic fatty acid synthase inhibtor. A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PH11B were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: fatty acid synthase inhibition The expression profiles of Trichophyton rubrum treated with PH11B were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2007-11-21 | E-GEOD-6336 | biostudies-arrayexpress

Transcriptional profiles of T.rubrum treated with PHS11A

Project description:A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PHS11A, a fatty acid synthase inhibitor, were determined. The expression profiles of Trichophyton rubrum treated with PHS11A were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-06-25 | E-GEOD-6403 | biostudies-arrayexpress

Transcriptional profiles of T.rubrum treated with PHS11A

2007-11-30 | GSE6403 | GEO

Dermatophytes CGH based on a Trichophyton rubrum cDNA microarray

2010-05-04 | GSE7909 | GEO

Global transcription profiles of Trichophyton rubrum in response to Flucytosine

Project description:A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to 5-Flucytosine were determined. Keywords: Expression profiling by array The expression profiles of Trichophyton rubrum treated with 5-Flucytosine were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-05-19 | E-GEOD-12861 | biostudies-arrayexpress

Expression profiling of T.rubrum treated with Terbinafine

Project description:One antifungal agent, terbinafine(TRB), has specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to TRB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: original article The expression profiles of Trichophyton rubrum treated with TRB were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-06-26 | E-GEOD-6951 | biostudies-arrayexpress

Dermatophytes CGH based on a Trichophyton rubrum cDNA microarray

Project description:A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and comparative genome hybridization based on microarray procedures were carried out. Dermatophyte species are classified into three genera: Epidermophyton, Microsporum, and Trichophyton. To determine the relationship between these three groups comparative genome hybridization were used in our experiment. Trichophyton rubrum genmic DNA was reference DNA and labelled by Cy3 while the other dermatophytes genomic DNA were test DNA and labelled by CY5. Test and reference DNA were co-hybridized with the T. rubrum cDNA microarray and the numbers of genes shared between each species and T. rubrum were determined. Keywords: Comparative Genomic Hybridization We used a Trichophyton rubrum cDNA microarray prepared in our lab through comparative genome hybridization of genomic DNA of 21 dermatophyte strains (belonging to 20 species) to elucidate the taxonomy and evolution profiles of 20 dermatophyte species. The numbers of genes shared between each species and T. rubrum were determined. Each strain DNA hybridized for 3 times. The slides were separated into three groups base on different datasets.

2010-05-03 | E-GEOD-7909 | biostudies-arrayexpress

Global transcription profiles of Trichophyton rubrum in response to Flucytosine

2008-09-23 | GSE12861 | GEO

Expression profiling of T.rubrum treated with Terbinafine

2008-02-04 | GSE6951 | GEO

Expression profiling of T. rubrum treated with amphotericin B and ketoconazole

Project description:Two antifungal agents, ketoconazole (KTZ) and amphotericin B (AMB), have specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to KTZ and AMB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: comparison of expression status

2007-05-30 | GSE5014 | GEO

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