Genomics

Dataset Information

164

Inhibition of transcriptional elongation in the P5424 T cell line


ABSTRACT: We study the impact of inhibiting Pol II-Se2 phosphorylation on Pol II binding and histone modifications in the mouse T cell line P5424. Overall design: Genome-wide analysis via ChIP-Seq for total RNA Pol II binding, H3K4me1, H3K4me2 and H3K4me3 in murine P5424 cells with tow conditions: KM05283 treatment (Inhibitor of Pol II Ser2 phosphorylation) or control DMSO.

INSTRUMENT(S): Illumina Genome Analyzer II (Mus musculus)

SUBMITTER: Mohamed BELHOCINE  

PROVIDER: GSE63416 | GEO | 2015-03-23

SECONDARY ACCESSION(S): PRJNA267698

REPOSITORIES: GEO

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Publications


V(D)J recombination assembles Ag receptor genes during lymphocyte development. Enhancers at AR loci are known to control V(D)J recombination at associated alleles, in part by increasing chromatin accessibility of the locus, to allow the recombination machinery to gain access to its chromosomal substrates. However, whether there is a specific mechanism to induce chromatin accessibility at AR loci is still unclear. In this article, we highlight a specialized epigenetic marking characterized by hig  ...[more]

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