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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [SREBP]

ABSTRACT: Data from SREBP1c binding to the genome was visualized using Genome Browser (UCSC) in order to test its role in Mafb transcriptional regulation

ORGANISM(S): Mus musculus

PROVIDER: GSE63697 | GEO | 2015/02/04

SECONDARY ACCESSION(S): PRJNA268825

REPOSITORIES: GEO

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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [SREBP]

Project description:Data from SREBP1c binding to the genome was visualized using Genome Browser (UCSC) in order to test its role in Mafb transcriptional regulation SREBP ChIP was performed in thioglycollate-elicited peritoneal macrophages treated as indicated.

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Project description: Not available

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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Microarrays analysis of SREBP-1a and SREBP-1c target genes identify new regulatory pathways.

Project description:In this study we have identified the target genes of SREBP1a and SREBP1c in primary cultures of human skeletal muscle cells using adenoviral vectors expressing the mature nuclear form of human SREBP1a or SREBP1c combined with oligonucleotide microarrays. Keywords: comparison of human myotubes infected either by SREBP1a or 1C Human myotubes were prepared from 3 different skeletal muscle biopsies. After 7 days of differentiation, myotubes were infected for 48 hours with recombinant adenovirus expressing either Renilla, nuclear SREBP1a or nuclear SREBP1c. Each SREBP1a or SREBP1c infected myotubes culture was compared to Renilla infected myotubes culture. Renilla infected myotubes were considered as the control. Three biological replicates were processed.

2010-05-26 | E-GEOD-10918 | biostudies-arrayexpress

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