Genomics

Dataset Information

64

Whole transcriptome of Lewis lung carcinoma cells of Mus musculus


ABSTRACT: Purpose: To study the alteration of whole transcriptome of Lewis lung carcinoma (LLC) cells after the decreasing of malignant properties of tumor by treatment of tumor-bearing mice with RNase A. Methods: Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5. The sequence reads were mapped by Bioscope 1.3 software, differential expression was evaluated by Cufflinks v.2.0.1 package. Results: Difference in expression was found for 966 genes. Conclusions: Our study represents the first detailed analysis of alteration of transcriptome of Lewis lung carcinoma after the decrease of malignant prtoperties of the tumor (proliferation and invasion) by RNase A. Overall design: Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5.

INSTRUMENT(S): AB 5500xl Genetic Analyzer (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Evgeniy Brenner  

PROVIDER: GSE63758 | GEO |

SECONDARY ACCESSION(S): PRJNA269015

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE63758_fpkm.txt.gz Txt
GSE63758_gene_exp.diff.gz Other
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